Whitening effect of triterpenoids from Poria cocos

Views:6     Author:Site Editor     Publish Time: 2021-07-21      Origin:Site

Whitening effect of triterpenoids from Poria cocos

Edited by Stephy


Poria cocos is the dry sclerotia of the fungus Poria cocos, which has the characteristics of medicine and food homology. Its main chemical components are polysaccharides and triterpenoids. Modern pharmacology has preliminarily proved that Poria cocos triterpenoids have many excellent skin whitening pharmacological activities.


1. The total triterpenoids of Poria cocos have certain antioxidant capacity and scavenging effect on DPPH and ABTS free radicals.


2. The total triterpenoids of Poria cocos and pachymenic acid A had significant inhibitory effect on tyrosinase bisphenol enzyme in a dose-dependent manner, with the concentration of 10.42-166.67 μ the inhibitory effect of total triterpenoids of Poria cocos was better than that of arbutin; The concentration of pachymenin a was 166.67% μ When the concentration of nicotinamide and arbutin was 1 g / ml, the inhibition effect was the best, which was better than that of nicotinamide and arbutin. At a concentration of 200 μ At this concentration, there was no significant difference in the inhibitory effect of total triterpenoids of Poria cocos, pachymenic acid A and arbutin on tyrosinase activity, but they were stronger than nicotinamide, another positive control drug. The possible mechanism of action is to change the three-dimensional structure of tyrosinase by binding with DOPA quinone and changing the hydrophobic environment of amino acid residues.


3. The total triterpenoids of Poria cocos and pachymenic acid a have certain cytotoxicity on mouse melanoma cells, which may achieve whitening effect by inhibiting the proliferation of B16 cells. The IC50 value of total triterpenoids of Poria cocos on cell proliferation was 118.26 μ The IC50 of pachymenic acid A was 48.01 g / ml μ g/ml。 Total triterpenoids of Poria cocos and pachymenic acid A could significantly inhibit tyrosinase activity in mouse B16 cells, and the concentration and inhibition rate showed a significant dose effect relationship, when the concentration reached 12.5 μ 86% and 39. 53% respectively.


Related studies showed that the antioxidant activity, inhibition of mushroom tyrosinase activity and the effect on mouse B16 cells of total triterpenoids and pachymenin a of Poria cocos provided a certain theoretical basis and scientific basis for the application of Poria cocos in whitening and skin care.


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