Which organs like NMN and which don't?

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Which organs like NMN and which don't?


The synthetase and depletion enzymes of NMN also have tissue specificity:


NMN is widely distributed in whole body tissues and organs, and exists in a variety of cells from the embryonic development period.


Little is known about the metabolism and biodistribution of NAD+ precursors in various tissues and cells. In contrast, the expression of NMN synthetase NAMPT and NRKs, and NMN depletion enzyme NMNATs are more understood.


(1) NAMPT


NAMPT is ubiquitous in the body, but there are big differences in expression levels between tissues. In the brain and heart, the NAMPT-dependent remedial pathway is the preferred mode of NAD+ production; in skeletal muscle, the NRK-dependent remedial pathway is the preferred mode of NAD+ production.


(2) NMNATs (NMN depleting enzymes)


The metabolic profile of mouse tissues shows that the activity of NMNAT subtypes is much higher than that of NAMPT, and the activity of NMNAT subtypes in most tissues is not restricted except for blood.


(3) NRKs


The expression analysis of NRK subtypes shows that NRK1 is ubiquitous, while NRK2 is mainly present in skeletal muscle. Consistent with this, chronic NR supplementation causes an increase in muscle NAD+ levels, but has little effect in the brain or white adipose tissue.


Oral NMN promotes NAD+:


Although the complete structure of NMN cannot be detected in the serum, take NMN orally can still quickly (15min) increase the NAD+ level of female and male mice:


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