Pressure reliever——Withania somnifera

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Withania somnifera 

   Withania somnifera one of the hottest dietary supplements, which is widely used, including anti-cancer, neuroprotection, diabetes treatment, antibacterial, cardiovascular protection, stress relief, anti-inflammatory and other directions.

In China, the application of stress relief supplements is relatively small, but as a potential supplement, South African drunk eggplant can play a greater role in the market, providing consumers with a natural and plant-based stress relief option.

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active ingredient

The active ingredients in Withania somnifera include steroidal lactones, alkaloids, saponins, etc. Among them, steroidal lactones (withanolides) are considered to be one of the main effective ingredients. Withaferin A, a derivative of withaferin A, is also the most studied solanolide.


Efficacy and mechanism

Withania somnifera has been widely studied abroad, covering the field of neurobrain health, including Alzheimer's disease, Parkinson's disease, depression, schizophrenia, anxiety, etc. In addition, for arthritis, diabetes and improving male fertility, the clinical research literature of drunk eggplant in South Africa is also quite rich. These studies not only expand the understanding of the efficacy of South African drunk eggplant, but also provide scientific support for its application in many health fields.

  • Anti-cancer

  • Neuroprotection

  • Anti-diabetic

  • Anti-microbial

  • Anti-inflammatory

  • Cardioprotection and anti-stress


FROM:Dar NJ, Hamid A, Ahmad M. Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cell Mol Life Sci. 2015 Dec; 72(23):4445-60.


Anti-diabetic mechanisms


  • Withania somnifera  can protect the pancreas β Cells, promoting insulin release.

  • inhibition α- Glucosidase and α- Amylase, while stimulating glucose transport, accelerates the transport of glucose ingested by the human body into cells.

  • In addition to improving glucose tolerance, it can also reduce insulin resistance to improve insulin sensitivity.



As a dietary supplement, Withania somnifera  is widely used in the health care market. Its claimed benefits include stress relief, emotional balance and body support. In the field of daily chemicals, the products derived from Withania somnifera  include essential oil, hair oil, essence and bath lotion, which are widely used in human skin care.



Use contraindications

  • Forbidden for pregnant women: high dose of Withania somnifera is considered to cause abortion of pregnant women, so it should be avoided during pregnancy.

  • It is forbidden for patients with hyperthyroidism: Withania somnifera is believed to improve the thyroid hormone levels (T3, T4), so patients with hyperthyroidism should avoid using it to avoid causing thyroid dysfunction.

  • It is forbidden for individuals taking sleeping drugs and sedative drugs: due to the sedative effect of Withania somnifera, it may interact with sleeping drugs or sedative drugs, resulting in drowsiness or more serious side effects.

  • Patients with benign prostatic hyperplasia / cancer: South African drunk eggplant is believed to increase testosterone levels in men, so it is also recommended to avoid the use of Withania somnifera in patients with hormone sensitive benign prostatic hyperplasia or cancer.

When considering the use of Withania somnifera or other dietary supplements, especially for people with chronic diseases, being treated with drugs or pregnant, it is best to consult the advice of medical professionals before use to ensure safety and applicability. Following professional advice can help ensure that the use of dietary supplements does not adversely affect the health of individuals.


1. Lopresti A L, Smith S J. Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: a systematic review of human trials[J]. Journal of Herbal Medicine, 2021, 28: 100434.

2. Langade D, Thakare V, Kanchi S, et al. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study[J]. Journal of Ethnopharmacology, 2021, 264: 113276.

3. Dutta R, Khalil R, Green R, et al. Withania somnifera (Ashwagandha) and withaferin A: Potential in integrative oncology[J]. International journal of molecular sciences, 2019, 20(21): 5310.

4. Langade D, Kanchi S, Salve J, et al. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study[J]. Cureus, 2019, 11(9).

5. Sharma A K, Basu I, Singh S. Efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial[J]. The Journal of Alternative and Complementary Medicine, 2018, 24(3): 243-248.

6. Chengappa K N R, Brar J S, Gannon J M, et al. Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in schizophrenia: a randomized, double-blind, placebo-controlled study[J]. The Journal of Clinical Psychiatry, 2018, 79(5): 22496.

7. Choudhary D, Bhattacharyya S, Bose S. Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions[J]. Journal of dietary supplements, 2017, 14(6): 599-612.

8. Katti A, Ashok B K, Murthy N A. Effect of Ashwagandha ghrita matrabasti on knee osteo arthritis of elderly population[J]. International Journal of Research in Ayurveda and Pharmacy, 2016, 7(1): 84-89.

9. Nagashayana N, Sankarankutty P, Nampoothiri M R V, et al. Association of L-DOPA with recovery following Ayurveda medication in Parkinson’s disease[J]. Journal of the neurological sciences, 2000, 176(2): 124-127.

10. Abedon B, Auddy B, Hazra J, et al. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study[J]. JANA, 2008, 11.

11. Biswal B M, Sulaiman S A, Ismail H C, et al. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients[J]. Integrative cancer therapies, 2013, 12(4): 312-322.

12. Biswal B M, Sulaiman A M, Ismail H C, et al. AOS14 Phase II clinical study of combination chemotherapy with herb Withania somnifera (ashwagandha) in breast cancer[J]. European Journal of Cancer, 2012, 48: S8-S9.

13. Kumar G, Srivastava A, Sharma S K, et al. Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study[J]. The Indian journal of medical research, 2015, 141(1): 100.

14. Ramakanth G S H, Kumar C U, Kishan P V, et al. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain[J]. Journal of Ayurveda and integrative medicine, 2016, 7(3): 151-157.

15. Rajoria K, Singh S K, Sharma R S, et al. Clinical study on Laksha Guggulu, Snehana, Swedana & traction in osteoarthritis (knee joint)[J]. Ayu, 2010, 31(1): 80.

16. Sumantran V N, Chandwaskar R, Joshi A K, et al. The relationship between chondroprotective and antiinflammatory effects of Withania somnifera root and glucosamine sulphate on human osteoarthritic cartilage in vitro[J]. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2008, 22(10): 1342-1348.

17. Anwer T, Sharma M, Pillai K K, et al. Effect of Withania somnifera on insulin sensitivity in non‐insulin‐dependent diabetes mellitus rats[J]. Basic & clinical pharmacology & toxicology, 2008, 102(6): 498-503.

18. Usharani P, Fatima N, Kumar C U, et al. Evaluation of a highly standardized Withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double blind, placebo controlled study[J]. Int. J. Ayurveda Pharma Res, 2014, 2: 22-32.

19. Udayakumar R, Kasthurirengan S, Mariashibu T S, et al. Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats[J]. International journal of molecular sciences, 2009, 10(5): 2367-2382.

20. Usharani P, Fatima N, Kumar C U, et al. Evaluation of a highly standardized Withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double blind, placebo controlled study[J]. Int. J. Ayurveda Pharma Res, 2014, 2: 22-32.

21. Usharani P, Kishan P V, Fatima N, et al. A comparative study to evaluate the effect of highly standardised aqueous extracts of Phyllanthus emblica, withania somnifera and their combination on endothelial dysfunction and biomarkers in patients with type II diabetes mellitus[J]. International Journal of Pharmaceutical Sciences and Research, 2014, 5(7): 2687.

22. Anwer T, Sharma M, Pillai K K, et al. Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats[J]. Acta Pol Pharm, 2012, 69(6): 1095-1101.

23. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study[J]. BioMed research international, 2015, 2015.

24. Ambiye V R, Langade D, Dongre S, et al. Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study[J]. Evidence-Based Complementary and Alternative Medicine, 2013, 2013.

25. Gannon J M, Forrest P E, Chengappa K N R. Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder[J]. Journal of Ayurveda and integrative medicine, 2014, 5(4): 241.

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