NMN and Male Function（II）

NMN and Male Function（II）

Edited by Tina

In the last article, we talked about supplementing NMN, that is, increasing NAD+ can relax smooth muscle. In this article, let us talk about how NMN can help men improve testosterone.

NAD+ can help men improve testosterone

Testosterone is a very important steroid hormone for men. Most of the testosterone is produced by the testicles. It is mainly used to maintain male body function, muscle strength and mass, and maintain bone density.

This important substance will gradually decrease with age. It has been reported that when a man reaches 80, his testosterone content in his body is only 1/50 of that of his youth. Lack of testosterone can lead to decreased muscle mass and quantity, loss of libido and even erectile dysfunction, loss of hair, loose bones, irritability, etc.

NMN improves testosterone mainly by regulating the SIRT1 gene in the body. Experiments show that NAD+ helps male mice produce testosterone by mediating the SIRT1 response, and NMN is a direct source of increasing NAD+ in humans. SIRT1 is a deacetylase dependent on NAD+. In the experiment, after knocking out part of the SIRT1 gene of male mice so that the mice could not produce SIRT1, the testosterone in the testes of male mice was 5 times lower than that of normal mice. Due to the lack of SIRT1, NAD+ cannot regulate the hypothalamus of male mice, resulting in a decrease in testosterone in the testes.[2]

The experimental results prove that: NAD+ mediates SIRT1 to regulate the internal environment balance of steroids, and the decrease of NAD+ content will weaken the function of SIRT1, and the testosterone content in mice will also decrease.

Reference

U. Kolthur-Seethara, "The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling," Biology of Reproductive , vol. 80, no. 2, 2009.