L-Reduced Glutathione

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L-Reduced Glutathione (GSH) is the master antioxidant naturally found in every cell of the human body. As a tripeptide, its critical roles in detoxification and antioxidant defense are essential for cellular health and vitality.


Efficacy 1: Master Antioxidant and Cellular Protection


  • Mechanism of Action: GSH works directly to neutralize free radicals and reactive oxygen species (ROS). It is the critical substrate for the enzyme Glutathione Peroxidase, which converts harmful hydrogen peroxide into harmless water. Furthermore, GSH is essential for regenerating other key antioxidants, such as Vitamin C and Vitamin E, returning them to their active form. By protecting mitochondrial function, GSH is vital for maintaining cellular energy and preventing cellular damage.


Glutathione_ Mechanism of Action - visual selection

  • Supporting Data: Clinical and biochemical studies consistently demonstrate that supplemental reduced glutathione can significantly boost the body's total antioxidant capacity, particularly when formulated for high bioavailability. Research links healthy GSH levels to improved immune function and protection against age-related oxidative stress.



Efficacy 2: Detoxification and Liver Health Support


  • Mechanism of Action: GSH plays a central role in Phase II detoxification in the liver. It directly conjugates with fat-soluble toxins, heavy metals, and xenobiotics (foreign chemical compounds), making them water-soluble and easily excreted from the body via urine or bile. Adequate GSH levels are necessary for the liver to neutralize these harmful substances and maintain optimal function.

Glutathiones Role in Liver Detoxification_ A Deep Dive - visual selection

  • Supporting Data: Supplementation with L-Reduced Glutathione has been clinically explored to support liver enzyme function. It is a vital component in protocols used to manage acute toxic load, highlighting its essential role as the liver's primary defense agent against chemical harm.




3. Market Applications


L-Reduced Glutathione is a high-value ingredient essential for advanced anti-aging, immune support, and detoxification formulations.

  • Dietary Supplements: Primarily used in capsules, tablets, liposomal liquids, and sublingual forms to maximize absorption.

    • Dosage: Typical daily doses range from 250mg to 1000mg, depending on formulation and therapeutic goals.

    • Target Population: Individuals focused on anti-aging, immune optimization, liver detoxification, and athletic recovery.

  • Cosmetics & Dermatology: Used in topical applications for skin brightening and anti-aging benefits due to its antioxidant properties and inhibition of melanin synthesis.



4. Our Advantages


  • Product Comparison:

    • High Purity & Bioactivity: Our L-Reduced Glutathione is synthesized to a guaranteed purity of $\ge$ 98.0%, ensuring maximum biological activity. We prioritize the reduced form (GSH) for direct cellular utilization, unlike oxidized forms (GSSG) often found in lower-quality products.

    • Advanced Quality Control: Every batch undergoes rigorous HPLC testing to confirm purity and compliance, exceeding standard industry requirements for stability and heavy metal content.

    • Exceptional Stability Profile: Our material is engineered for superior stability, ensuring the active reduced form is maintained throughout your product's shelf life, addressing common formulation challenges.

  • Technical Expertise: We provide specialized technical guidance on solubility, stability studies, and formulating for maximum bioavailability (e.g., in liposomal or sustained-release delivery systems).

  • Global Compliance: Produced in a cGMP, ISO, and HACCP certified facility, our product meets strict regulatory standards worldwide.


Reference Citations:

    Pastore, A., et al. (2016). Glutathione metabolism and its alterations in hepatic diseases. Clinical Chemistry and Laboratory Medicine (CCLM), 54(12), 1957-1967.

    Pizzorno, J. (2014). Glutathione! Integrative Medicine: A Clinician's Journal, 13(1), 8–12.

    Sekhar, R. V., et al. (2011). Glutathione synthesis is diminished in older humans and contributes to oxidative stress. Proceedings of the National Academy of Sciences, 108(22), 8812-8817.

    Richie, J. P., et al. (2015). Randomized controlled trial of oral $\text{N-acetylcysteine}$ (NAC) plus $\text{L-glutathione}$ on muscle strength and fatigue in older adults. Clinical Nutrition, 34(3), 415-420.


If you are interested in our L-Reduced Glutathione or require technical support for formulation, please contact us.


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Product Inquiry
  • Q Do you manufacture all natural products?

    A Yes, we manufacture products with no artificial ingredients.
  • Q Can I have a sample ?

    A Sure, 20g-50g free sample is available for your testing.
  • Q Do you have a guarantee on your products?

    A We guarantee the goods produced is same as the samples confirmed by you, and strictly tested every item comply with CHP, EP or USP before shipping.
  • Q What is your delivery?

    A Normally the delivery is 7-10 working days
  • Q What do you produce?

    A We produce standardized herbal extract to ratio extract, such as Pesticide Free Ginseng Extract, Cocoa Polyphenols, Apple Phloridzin, Sweet Tea Extract, Resveratrol From Giant Knotweed Extract, Sorghum Extract, Dong Quai Extract, Milk Thistle Extract, Red Clover Extract, Echinacea Purpurea Extract, Magnolia Bark Extract etc
We look forward to working with you to develop cost effective products and long term relationships with mutual benefit.

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